Home > Faculties > Son, Young Sook

Son, Young Sook
Professor, Tissue Engineering Lab.
Tel: 82-31-201-3822
E-mail: ysson@khu.ac.kr
BS, Seoul National University, Food Science and Nutrition (1976-1980)
MS, Seoul National University, Microbiology (1980-1982)
Ph.D., University of California San Francisco, Pharmacology (1985-1989)
Post-Doctoral Research Associate, The University of Chicago, HHMI (1989-1991)
Lab Chief, Korea Institute of Rad. & Med. Science (1993-2006)
Center Director, Musculoskeletal Bioorgan Center of MOHW (2004-present)
Professor, Kyung Hee University, Genetic Engineering (2006-present)

The Laboratory of Tissue Engineering is presently studying several research topics in the field of regenerative medicine for the development of cell therapies and bio-organs such as the identification of stem cells, control of cell differentiation, mass culture of stem cells, tissue engineering scaffold design, and cell preconditioning.

-Identification of stem cell by side-population phenotype
-Transdifferentiation of neural precursor cells
-Mobilization of mesenchymal stem cells from bone marrow by substance p
-Dedifferentiation and redifferentiation of costal chondrocytes
-Mechanical stimuli-activated signaling pathway and cell preconditioning
-Cell therapeutic development for skin injury Mechanism of wound healing
-Development of tissue engineering scaffold Animal models for spinal cord injury, corneal injury, articular cartilage injury, and wound healing.

Neural precursor cells for regeneration of spinal cord injury (2004-2011 by 21st New Frontier Project: Stem Cell Research Center), Musculoskeletal Bioorgan Center (2004-2013 by the Ministry for Health, Welfare and Family Affairs), Development of New Therapeutic Technology Based on Molecular Imaging for Intractable Diseases (2005.12-2010.11, supported by Seoul city)

1. Lee EA, Yi JY, Chung EK, Son YS(2009), Transforming growth factor beta1 transactivates EGFR via an H2O2-dependent mechanism in squamous carcinoma cell line. Cancer Letter (In Press)

2. Hong HS, Lee JS, Lee EunAh, Kwon YS, Lee EK, Ahn WS, Jiang MH, Kim JC and Son YS (2009), A new role of substance P as a injury-inducible messenger for mobilization of CD29+ stromal-like cells. Nature Medicine, 15:425-435

3. Kang MH, Kim DY, Yi JY, and Son YS (2009), Substance P accelerates intestinal tissue regeneration after g-irradiation-induced damage. Wound Rep. Reg. 17:216-223

4. Lee JS, Lee JY, Lee EK, Son YS (2009), Newborn Calf Serum Retards Loss of Chondrocytic Phenotype during In Vitro Cell Expansion. Tissue Engineering and Regenerative Medicine, 6:229-235

5. Lee EK, Lee JS, Son YS (2008), Distinct Expression Profiles in Type III Collagen and a-Smooth Muscle Actin between Human Dental Pulp Stem Cells and Human Mesenchymal Stem Cells. Tissue Engineering and Regenerative Medicine, 5:559-564

6. Son YS, Lee DS, Lee JY, Chi G (2008), Induction of Nestin-expressing Spheroids from Human Dermal Fibroblastinab FGF-dependent Manner. International Journal of Stem Cells 1: 82-90

7. Lee EK, Lee JS, Son YS (2008), Distint Expression Profiles in Type III Collagen and αSmooth Muscle Actine between Human Dental Pulp Stem Cells and Human. Tissue Engineering and Regenerative Medicine 5:559-564

8. Lee SJ, Son YS, Kim CH, Choi MS (2007), Fabrication of micropatterned fibronectin for studying adhesion and alignment behavior of human dermal fibroblasts. Macro mol Res, 5: 348-356

9. Lee JS, Lee EK, Kim HY, Son YS (2007), Comparison of articular cartilage with costal cartilage in initial cell yield, degree of dedifferentiation during expansion and redifferentiation capacity. Biotechnol Appl Bioc, 48:149-158

10. Youn YH, Kim CH, Choi YJ, Gin YG, Son YS (2006) Increase in the biocompatibitility of the neutralzed chitosan dermal scaffold by reconstruction of wound healing microenvironment: in vitro study. Key Engineering Materials 342:185-188

11. Lee HJ, Choi BH, Min BH, Son YS, Park SR, (2006) Low-internsity Ultrasound Stimulation Enhances Chondrogenic Differentiation In Alginate Culture of Mesenchymal Stem Cells, Artif organ, 30:707-715

12. Park KS, Lim CH, Min BM, Lee JL, Chung HY, Joo CK, Park CW, Son YS (2006), The Side population cells in the rabbit limbus sensitively increased in response to the central cornea wounding. Invest. Ophthal. Vis. 47:892-900

13. Choi YJ, Choung SK, Hong CM, Shin IS, Park SN, Hong SH, Park HK, Park YH, Son YS, Noh IS (2005), Evaluations of blood compatibility via protein adsorption treatment of the vascular scaffold surfaces fabricated with polylactide and surface-modified expanded polytetrafluoroethlene for tissue engineering applications. J. Biomed. Mater. Res. 75:824-831

14. Kwon YS, Hong HS, Kim JC, Shin JS, Son YS (2005), Inhibitory effect of Rapamycin on corneal neovascularization in vitro and in vivo. IOVS, 46:454-460

15. Lee EK, Lee JS, Park HS, Kim CH,Gin YJ, Son YS (2005), Cyclic stretch stimulates cell proliferation of human mesenchymal stem cells but do not induce their apoptosis and differentiation. Tissue Engineering and Regenerative Medicine, 2:29-33

16. Park HS, Kang HJ, Han KB, Han ES, Kim CH, Gin YJ, Kim TH, Son YS. (2004), Application of physical force is essential to enrich epidermal stem cell in the process of primary human keratinocyte isolation. Tissue Engineering, 10:343-351

17. Bae JS, Park HS, Son YS, Bae-Lee E, Kim IS (2002) Big-h3 supports keratinocyte adhesion, migration, and proliferation through alpha3beta1 integrin. Biochem Biophy. Res. Comm. 294:940-8

18. Jae Youn Yi, Kyu Chung Hur, EunAh Lee, Yong Jae Jin, Carlos L. Arteaga, Young Sook Son, (2002), TGF beta 1 mediated epithelial to mesenchymal transition is accompanied by invasion in the SiHa cell line, European Journal of Cell Biology, 81:457-68

19. Chun Ho Kim, Chang Hwan Kim, Hyun Sook Park,Young Sook Son.(2002), Chitosan-based dermal scaffolds, Macromol. Chem.Symp 15:165-174

20. Use of substance P for mobilization of mesenchymal stem cells for proliferation of mesenchymal stem cells and for wound healing or facilitating wound healing, Son et al, EU #1 658 855(Jan 25th,2009)