We are presently conducting research on several projects related to medical and plant biotechnology. In the field of medical biotechnology, we are investigating the molecular mechanisms of tumstatin and canstatin in cancer cells using genomics and molecular biology methods. We are also analyzing the effects of tumstatin and canstatin in AT-84 and CT-26 animal models.

We also plan to develop molecular target therapy for human carcinomas using tumstatin and canstatin in future clinical trials. In the field of plant biotechnology, we are investigating the genetic engineering of plants for recombinant protein production with a major focus on vaccines and therapeutics.

- Investigation of molecular mechanisms of tumstatin and canstatin in cancer cells using genomics and molecular biology methods
- Molecular target therapy for human carcinomas using tumstatin and canstatin
- Development of edible vaccines against human rotavirus and hepatitis A virus diseases
- Bioreactor design and scale-up for the production of biopharmaceuticals

1. Im J, Jeon JH, Cho MK, Woo SS, Kang SS, Yun CH, Lee K, Chung DK, Han SH. (2009) Induction of IL-8 expression by bacterial flagellin is mediated through lipid raft formation and intracellular TLR5 activation in A549 cells. Mol Immunol. in press.

2. Lee JM, Shin JW, Nam JK, Choi JY, Jeong CS, Han IS, Nam SW, Choi YJ, Chung DK. (2009) Molecular cloning and expression of the trichoderma harzianum C4 endo-beta-1,4-Xylanase Gene in Saccharomyces cerevisiae. J Microbiol Biotechnol. 19(8):823-8.

3. Lee TH, Lee GW, Kim CW, Bang MH, Baek NI, Kim SH, Chung DK, Kim J. (2009) Stewartia koreana extract stimulates proliferation and migration of human endothelial cells and induces neovasculization in vivo. Phytother Res. in press

4. Ryu YH, Baik JE, Yang JS, Kang SS, Im J, Yun CH, Kim DW, Lee K, Chung DK, Ju HR, Han SH. (2009) Differential immunostimulatory effects of Gram-positive bacteria due to their lipoteichoic acids. Int Immunopharmacol. 9(1):127-33.

5. Lee DY, Yoo KH, Chung IS, Kim JY, Chung DK, Kim DK, Kim SH, Baek NI. (2008) A new lignan glycoside from the fruits of Cornus kousa Burg. Arch Pharm Res. 31(7):830-3.

6. Baek S, Kim J, Kim D, Lee C, Kim J, Chung DK, Lee C. (2008) Inhibitory effect of dalbergioidin isolated from the trunk of Lespedeza cyrtobotrya on melanin biosynthesis. J Microbiol Biotechnol. 18(5):874-9.

7. Kim HG, Lee SY, Kim NR, Ko MY, Lee JM, Yi TH, Chung SK, Chung DK. (2008) Inhibitory effects of Lactobacillus plantarum lipoteichoic acid (LTA) on Staphylococcus aureus LTA-induced tumor necrosis factor-alpha production. J Microbiol Biotechnol. 18(6):1191-6.

8. Kim HG, Kim JY, Gim MG, Lee JM, Chung DK. (2008) Mechanical stress induces tumor necrosis factor-{alpha} production through Ca2+ release-dependent TLR2 signaling. Am J Physiol Cell Physiol. 295(2):C432-9.

9. Song MC, Nigussie F, Yang HJ, Kim HH, Kim JY, Chung DK, Baek NI. (2008) Phenolic glycosides from Lindera fruticosa root and their inhibitory activity on osteoclast differentiation. Chem Pharm Bull (Tokyo). 56(5):707-10.

10. Kim HG, Kim NR, Gim MG, Lee JM, Lee SY, Ko MY, Kim JY, Han SH, Chung DK. (2008) Lipoteichoic acid isolated from Lactobacillus plantarum inhibits lipopolysaccharide-induced TNF-alpha production in THP-1 cells and endotoxin shock in mice. J Immunol. 180(4):2553-61.

11. Lee KH, Park JY, Jeong SJ, Kwon GH, Lee HJ, Chang HC, Chung DK, Lee JH, Kim JH. (2007) Characterization of paraplantaricin C7, a novel bacteriocin produced by Lactobacillus paraplantarum C7 isolated from kimchi. J Microbiol Biotechnol. 17(2):287-96.

12. Lee KH, Park WJ, Kim JY, Kim HG, Lee JM, Kim JH, Park JW, Lee JH, Chung SK, Chung DK. (2007) Development of a monitoring vector for Leuconostoc mesenteroides using the green fluorescent protein gene. J Microbiol Biotechnol. 17(7):1213-6.

13. Cheon IS, Woo SS, Kang SS, Im J, Yun CH, Chung DK, Park DK, Han SH. (2008) Peptidoglycan-mediated IL-8 expression in human alveolar type II epithelial cells requires lipid raft formation and MAPK activation. Mol Immunol. 45(6):1665-73.

14. Park CK, Kim HJ, Kwak HB, Lee TH, Bang MH, Kim CM, Lee Y, Chung DK, Baek NI, Kim J, Lee ZH, Kim HH. (2007) Inhibitory effects of Stewartia koreana on osteoclast differentiation and bone resorption. Int Immunopharmacol. 7(12):1507-16.

15. Hwang HJ, Moon CH, Kim HG, Kim JY, Lee JM, Park JW, Chung DK. (2007) Identification and functional analysis of salmon annexin 1 induced by a virus infection in a fish cell line. J Virol. 81(24):13816-24.

16. Lee TH, Kwak HB, Kim HH, Lee ZH, Chung DK, Baek NI, Kim J. (2007) Methanol extracts of Stewartia koreana inhibit cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) gene expression by blocking NF-kappaB transactivation in LPS-activated RAW 264.7 cells. Mol Cells. 23(3):398-404.

17. Kim HG, Gim MG, Kim JY, Hwang HJ, Ham MS, Lee JM, Hartung T, Park JW, Han SH, Chung DK (2007) Lipoteichoic acid from Lactobacillus plantarum elicits both the production of Interleukin-23p19 and suppression of pathogen-mediated Intereukin-10 in THP-1 cell . 2006 FEMS Immunol Med Microbiol 49(2):205-14.

18. Yang JS, Kim HJ, Ryu YH, Yun CH, Chung DK, Han SH. (2006) Endotoxin contamination in commercially available pokeweed mitogen contributes to the activation of murine macrophages and human dendritic cell maturation. Clin Vaccine Immunol. 13, 3:309-313

19. Yun CH, Chung DK,Yoon K, Han SH. (2006) nvolvement of reactive oxygen species in the immunosuppressive effect of 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indol(Trp-P-1), a food-born carcinogenic heterocyclic amine. Toxicol Letter. In press

20. EONG, SEON-JU, JAE-YONG PARK, JONG HWAN KIM, GYEONG MIN KIM, JIYEON CHUN,JONG-HOON LEE, DAE-KYUN CHUNG, AND JEONG HWAN KIM (2006) Transformation of Leuconostoc mesenteroides SY1, a Strain Isolated from Kimchi. Journal of Microbiology and Biotechnology 16, 1:149-152