Home > Faculties > Yoon, Jae Seung

Yoon, Jae Seung

Professor, Cell Biology Lab.
Tel: 031-201-2450
E-mail: jsyoon@khu.ac.kr

BS, Seoul National Univ., Microbiology (1979-1983)
MS. Seoul National Univ., Biochemistry (1983-1985)
Ph.D., Purdue Univ., Biology (1985-1990)
Postdoc, Purdue University (1990-1992)
Visiting Research Professor, Baylor College of Medicine (1998)
Visiting Research Professor, National University of Singapore (2002-2003)
Editor, Journal of Microbiology and Biotechnology (2000-2003)
Professor, Kyung Hee Univ., Genetic Engineering (1992-present)

We are presently conducting research on several projects:

(1) Investigation of the mechanisms of neurodegenerative diseases using Drosophila as an animal model system;
(2) Development of mammalian expression system and manufacturing process for recombinant protein therapeutics.


1. Park JS, Kim H, Park J, Yu S, Kim D, Lee J, Oh H, Baek K, Yoon J, (2009) Overproduction of recombinant human hepatocyte growth factor in Chinese hamster ovary cells. Protein Expr. Purif. in press.

2. Byun J, Yoon J, Baek K, (2009) Analysis of two promoters that control the expression of the GTP cyclohydrolase I gene in Drosophila melanogaster. Mol. Cells 27: 583-589.

3. Kim E, Choi Y, Lee S, Seo Y, Yoon J, Baek K, (2008) Characterization of the Drosophila melanogaster retinin gene encoding a cornea-specific protein. Insect Mol. Biol. 17: 537-543.

4. Lee S-B, Park JS, Lee S, Park J, Yu S, Kim H, Kim D, Byun TH, Baek K, Ahn Y-J, and Yoon J, (2008) Overproduction of recombinant human VEGF (vascular endothelial growth factor) in Chinese hamster ovary cells. J. Microbiol. Biotechnol. 18: 183-187.

5. Lee S, Leung H-T, Kim E, Jang J, Lee E, Baek K, Pak WL, Yoon J, (2007) Effects of a mutation in the Drosophila poringene encoding mitochondrial voltage-dependent anion channel protein on phototransduction. Dev. Neurobiol. 67: 1533-1545.

6. Park J, Yu S, Yoon J, Baek K, (2005) High-level expression of recombinant human bone morphogenetic protein-4 in Chinese hamster ovary cells. J. Miocrobiol. Biotechnol. 15: 1397-1401.

7. Kim J, Yoon Y, Hwang H-Y, Park JS, Yu S, Lee J, Baek K, Yoon J, (2005) Efficient selection of stable Chinese Hamster Ovary (CHO) cell lines for expression of recombinant proteins by using human interferon SAR element. Biotechnol. Prog. 21: 933-937.

8. Kim E, Kim D, Hwang H-Y, Yoon J, Yoon Y, Baek K. (2004) High-level expression of recombinant human interleukin-2 in Chinese Hamster Ovary cells using the expression system containing transcription terminator. J. Microbiol. Biotechnol. 14: 810-815.

9. Yoon J, Leung H, Lee S, Geng C, Kim Y, Baek K, Pak WL, (2004) Specific molecular alterations in the norpA-encoded phospholipase C of Drosophilaand their effects on electrophysiological response in vivo. J. Neurochem. 89: 998-1008.

10. Kim J, Kim J, Park D, Kang H, Yoon J, Baek K, Yoon Y, (2004) Improved recombinant gene expression in CHO cells using matrix attachment regions. J. Biotechnol. 107: 95-105.

11. Ryu Y, Oh Y, Yoon J, Cho W, Baek K, (2003) Molecular characterization of a gene encoding the Drosophila melanogaster phospholipase A2. Biochim. Biophys. Acta 1628: 206-210.

12. Hong YS, Park S, Geng C, Baek K, Bowman JD, Yoon J, Pak WL, (2002) Single amino acid change in the fifth transmembrane segment of the TRP Ca2+ channel causes massive degeneration of photoreceptors. J. Biol. Chem. 277: 33884-33889.

13. Park H, Seong C, Jang J, Yoon J, Han K, Cho N, Baek K, (2001) Promoter analysis of the Drosophila melanogaster gene encoding the pterin 4-carbinolamine dehydratase. Mol. Cells 12: 233-238.

14. Oh Y, Lee S, Yoon J, Han K, Baek K, (2001) Promoter analysis of the Drosophila melanogaster gene encoding transcription elongation factor TFIIS. Biochim. Biophys. Acta 1518: 276-281.

15. Choi T-Y, Cho N-Y, Oh Y, Yoo M-A, Matsukage A, Ryu Y, Han K, Yoon J, Baek K, (2000) The DNA replication-related element (DRE)-DRE-binding factor (DREF) system may be involved in the expression of the Drosophila melanogaster TBP gene. FEBS Letters 483: 71-77.

16. Seong C, Baek K, Yoon J, (2000) Structure, chromosomal localization, and expression of the Drosophila melanogaster gene encoding sepiapterin reductase. Gene 255: 357-361.

17. Yoon J, Ben-Ami HC, Hong YS, Park S, Strong LLR, Bowman J, Geng C, Baek K, Minke B, Pak WL, (2000) Novel mechanism of massive photoreceptor degeneration caused by mutations in the trp gene of Drosophila. J. Neurosci. 20: 649-659.