Home > Faculties > Kim, Ji Young

Kim, Ji Young
Professor, Molecular Biology Lab.
Tel: 82-31-201-2435
Fax : 82-31-203-4969
E-mail: jkim@khu.ac.kr

BS, Seoul National University, Food and Nutrition (1969-1973)
MS, University of Chicago, Biochemistry/Molecular Biology (1975-1976)
Ph.D., University of Chicago, Biochemistry/Molecular Biology (1977-1981)
Post-Doctoral Research Associate, California Institute of Technology (1981-1984)
Senior Research Scientist, KAIST Genetic Engineering Center (1984-1989)
Dean, Kyung Hee University, College of Life sciences (2005-2007)
Professor, Kyung Hee University, Genetic Engineering (1989-present)

Our research group is working on the regulation of chemokine genes in monocytic cell lines in response to various agonists in order to understand the regulatory roles of chemokines during inflammation. We have been the studying functional roles of chemokines in angiogenesis by analyzing endothelial cell migration and in vivo angiogenic activities. We are currently working on the migration and invasion of hepatoma cells which are induced by CCR1ligands.


Our research team is also interested in the functional roles of lactoferrin in the regulation of angiogenesis. We have shown that human lactoferrin upregulates VEGF-A-mediated angiogenesis via upregulation of KDR/Flk-1. We are currently investigating the roles of lactoferrin in the expression of cell adhesion molecules such as ICAM-1, VCAM-1, and E-selectin. In addition, we are also interested in plant-derived natural products which could be utilized for the prevention and treatment of inflammatory diseases and osteoporosis. Our group has developed screening systems for anti-inflammatory activities and anti-osteoporosis and through the screening of hundreds of plant extracts we have obtained a number of candidates for anti-inflammation and anti-osteoporosis. We are currently working on the molecular actions of such candidate extracts, the isolation of active compounds, and the development of functional materials.

- Function and signaling pathways of CC-chemokines in monocytes and endothelia cells.
- Roles of the chemokine, CCL23 (CKβ8), in CCR1-expressing hepatoma cells.
- Functional analysis of Lactoferrin on cell growth and angiogenesis through?receptor-mediated signaling.
- Screening and analysis of plant-derived natural products for immunomodulation and osteoporosis therapy.


1. Son KN, Hwang J, Kwon BS, Kim J. (2006) Human CC chemokine CCL23 enhances expression of matrix metalloproteinase-2 and invasion of vascular endothelial cells. Biochem Biophys Res Commun. 340(2):498-504.

2. Lee JH, Lee EO, Lee HJ, Kim KH, Ahn KS, Lee SJ, Kim J, Kim SH. (2006) DMNQ S-53 induces apoptosis and inhibits the growth of Lewis lung carcinoma cells in vitro and in vivo. Journal of Cardiothoracic-Renal Research 1:73-79

3. Kim CW, Son KN, Choi SY, Kim J. (2006) Human lactoferrin upregulates expression of KDR/Flk-1 and stimulates VEGF-A-mediated endothelial cell proliferation and migration. FEBS Lett. 580(18):4332-6.

4. Kim JY, Park SK, Kim HG, Cho SJ, Kim J, Kang CJ. (2006) The HSS3/4 enhancer of Crlz1-IgJ locus is another target of EBF in the pre-B cell stage of B cell development. Immunol Lett. 107(1):63-70.

5. Lim JH, Cho SJ, Park SK, Kim J, Cho D, Lee WJ, Kang CJ. (2006) Stage - Specific Expression of Two Neighboring Crlz1 and IgJ Genes during B cell Development Is Regulated by Their Chromatin Accessibility and Histone Acetylation. J. Immunol. 177: 5420-5429

6. Shin YH, Lee GW, Son KN, Lee SM, Kang J, Kwon BS, Kim J. (2007) Promoter analysis of human CC chemokine CCL23 gene in U937 monoytoid cells. Biohemia et Biophysia Acta (BBA) - Gene Structure and Expression 1769(3): 204-8.

7. Lee TH, Kwak HB, Lee HH, Lee ZH, Chung DK, Baek NI, Kim J. (2007) Methanol Extrats of Stewartia Koreana inhibit Cyclooxygenase-2(COX-2) and induible Nitric Oxide Synthase(iNOS) Gene Expression by bloking NF-kB Transactivation in LPS-activated RAW 264.7 cells. Mol. cells 23(3):

8. Oh SM, Lee SH, Lee BJ, Pyo CW, Yoo NK, Lee SY, Kim J, Choi sy. (2007) A Distint Role of Neutrophil Lactoferrin in RelA/p65 Phosphorylation on Ser536 by Reruiting TNF Reeptor-Assoiated Fators to IkB kinase Signaling complex. J. Immunol. 179(9):5686-5692

9. Park CK, Kim HJ, Kwak HB, Lee TH, Bang MH, Kim CM, Lee Y, Chung DK, Baek NI, Kim j, Lee ZH, Kim HH. (2007) Inhibitory effets of Stewartia Koreana on osteolast differentiation and bone resorption. Int. Immunopharmaol. 7(12):1507-1516.

10. Han KY, Kwon TH, Lee TH, Lee SJ, Kim SH, Kim J. (2008) Suppressive effets of Lithospermum erythorhizon extrats on lipopolysaccharide-indued activation of AP-1 and NF-kB via mitogen-activated protein kinase pathway in mouse macrophage cells. BMB rep. 41(4):328-333

11. Song MC, Nigussie F, Yang HJ, Kim HH, Kim JY, hung DK, Baek NI. (2008) Phenolic Glycosides from Lindera fruticosa Root and their Inhibitory Activity on Osteolast Differentiation. Chem. Pharm. Bull. 56(5):707-710

12. Lee DY, Yoo KH, hung IS, Kim JY, hung DK, Kim DK, Kim SH, Baek NI. (2008) A new lignan glycoside from the fruits of Cornus kousa Burg. Arch. Pharm. Res. 31(7):830-833

13. Lee HJ, Lee HJ, Magesh V, Nam D, Lee EO, Ahn KS, Jung MH, Ahn KS, Kim DK, Kim JY, Kim SH. (2008) Shikonin, acetylshikonin, and isobutyroylshikonin inhibit VEGF-induced angiogenesis and suppress tumor growth in lewis lung carcinoma-bearing mice. Yakugaku Zasshi 128(11):1681-1688.

14. Lee SH, Park SW, Pyo CW, Yoo NK, Kim J, Choi SY. (2009) Requirement of the JNK-associated Bcl-2 pathway for human lactoferrin-induced apoptosis in the Jurkat leukemia T cell line. Biochimie 91(1):102-108.

15. Han KY, Kim CW, Lee TH, Son Y, Kim J. (2009) CCL23 up-regulates expression of KDR/Flk-1 and potentiates VEGF-induced proliferation and migration of human endothelial cells. Biochem. Bioph. Res. Co. 382(1):124-128.

16. Lee TH, Lee GW, Kim CW, Bang MH, Baek NI, Kim SH, Chung DK, Kim J. (2009) Stewartia koreana extract stimulates proliferation and migration of human endothelial cells and induces neovasculization in vivo. Phytother. Res. [Epub ahead of print]

17. Song IS, Kim SU, Oh NS, Kim J, Yu DY, Huang SM, Kim JM, Lee DS, Kim NS. (2009) Peroxiredoxin I contributes to TRAIL resistance through suppression of redox-sensitive caspase activation in human hepatoma cells. Carcinogenesis 30(7):1106-1114.

18. Kim SA, Lee HJ, Ahn KS, Lee HJ, Lee EO, Ahn KS, Choi SH, Jung SJ, Kim JY, Baek N, Kim SH. (2009) Paeonol exerts anti-angiogenic and anti-metastatic activities through downmodulation of Akt activation and inactivation of matrix metalloproteinases. Biol. Pharm. Bull. 32(7):1142-1147.

19. Lee SH, Pyo CW, Hahm DH, Kim J, Choi SY. (2009) Iron-saturated lactoferrin stimulates cell cycle progression through PI3K/Akt pathway. Mol. Cells 28(1):37-42.

20. Lee JY, Jung HJ, Song IS, Williams MS, Choi C, Rhee SG, Kim J, Kang SW. (2009) Protective role of cytosolic 2-cys peroxiredoxin in the TNF-alpha-induced apoptotic death of human cancer cells. Free Radic. Biol. Med. [Epub ahead of print] 0891-5849